Broad Institute developed webapps allow users to query the over 1.4M L1000 experiments without having to download data.

Web Apps

Researchers can interact with LINCS data that is hosted on the cloud-based analysis system ( to perform analysis including:

  • Finding LINCS experiments, cell models and perturbagens of interest to their research area
  • Match L1000 signatures to user defined gene sets
  • Summarizing top connections by cell type and perturbagen type (i.e small-molecules, shRNA based knock-down and cDNA based over-expression)

How the data were prepared

The dataset consists of a collection of transcriptional expression data from cultured human cells treated with bioactive small molecules and genetic perturbagens profiled on the Broad Institutes L1000 assay.

Each of the cell lines tested is treated with a range of chemical and genetic perturbagens. The diversity of the cell lines and perturbagens used ensures that data are generated to address the widest possible range of biological research.

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