Perturbagens assayed

The L1000 dataset contains perturbagens profiled as part of the LINCS program, the Broad Connectivity Map, NIH efforts such as CDRP, and other projects. This page provides a snapshot (current as of April 2014) as to what perturbagens were profiled.

Note: These lists of perturbagens are provided for reference only. The current list of perturbagens assayed (along with their meta data) are best got by querying the Data API at api.lincscloud.org

  • 20,413 Small-molecule compounds. These compounds were selected from multiple sources. They include known drugs, pathway-specific tool compounds and those identified in NIH-sponsored small-molecule screening efforts. An important subset of the compounds have been nominated by members of the research community.
    • ~1,300 FDA-approved drugs
    • ~5585 bioactive tool compounds
    • 2,000+ screening hits (MLPCN and others)

    List of chemical perturbagens (excel file)

  • 22,119 Genetic constructs for knocking-down genes (shRNA) or over-expressing genes (cDNA). These constructs were designed to affect genes that are known targets of FDA-approved drugs, drug-target pathway members, those associated with disease. As with small-molecule compounds, a subset of the genes were nominated by the research community.
    • ~900 targets/pathways of FDA-approved drugs
    • ~600 candidate disease genes
    • 500+ community nominations

    List of genetic perturbagens (excel file)

Note: These lists of perturbagens are provided for reference only. The current list of perturbagens assayed (along with their meta data) are best got by querying the Data API at api.lincscloud.org